Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
نویسندگان
چکیده
منابع مشابه
Occupational exposure to diesel exhaust fumes.
There is currently no OEL for diesel fumes in the UK. This study reports parallel measurements of airborne levels of diesel fume pollutants in nine distribution depots where diesel powered fork-lift trucks (FLTs) were in use. Correlations between individual pollutants are assessed as well as their spatial distribution. Samples were collected on board FLTs and at background positions at nine dis...
متن کاملBronchoalveolar inflammation after exposure to diesel exhaust: comparison between unfiltered and particle trap filtered exhaust.
OBJECTIVES Air pollution particulates have been identified as having adverse effects on respiratory health. The present study was undertaken to further clarify the effects of diesel exhaust on bronchoalveolar cells and soluble components in normal healthy subjects. The study was also designed to evaluate whether a ceramic particle trap at the end of the tail pipe, from an idling engine, would r...
متن کاملPolyphosphate enhances fibrin clot structure.
Polyphosphate, a linear polymer of inorganic phosphate, is present in platelet dense granules and is secreted on platelet activation. We recently reported that polyphosphate is a potent hemostatic regulator, serving to activate the contact pathway of blood clotting and accelerate factor V activation. Because polyphosphate did not alter thrombin clotting times, it appeared to exert all its proco...
متن کاملAirway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans.
Pulmonary cells exposed to diesel exhaust (DE) particles in vitro respond in a hierarchical fashion with protective antioxidant responses predominating at low doses and inflammation and injury only occurring at higher concentrations. In the present study, the authors examined whether similar responses occurred in vivo, specifically whether antioxidants were upregulated following a low-dose DE c...
متن کاملAcute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways.
We have previously demonstrated that short-term exposure to diesel exhaust (DE) for 1 h induced a marked leukocytic infiltration in the airways of healthy human volunteers involving neutrophils, lymphocytes, and mast cells along with increases in several inflammatory mediators. We hypothesized that the leukocyte infiltration and the various inflammatory responses induced by DE were mediated by ...
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ژورنال
عنوان ژورنال: Particle and Fibre Toxicology
سال: 2010
ISSN: 1743-8977
DOI: 10.1186/1743-8977-7-17